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Distinctive genomic characteristics in POLE/POLD1-mutant cancers can potentially predict beneficial clinical outcomes in patient
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer | PLOS Genetics
Exome sequencing reveals a de novo POLD1 mutation causing phenotypic variability in mandibular hypoplasia, deafness, progeroid f
Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study
Church Group — Wellcome Centre for Human Genetics
DNA polymerase mutations as drivers of genome instability and cancer
POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction | BMC Medical Genetics | Full Text
Distribution of POLE mutations within the exonuclease domain. | Download Scientific Diagram
DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency - ScienceDirect
POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction | BMC Medical Genetics | Full Text
Genes | Free Full-Text | Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity | HTML
POLE proofreading defects: Contributions to mutagenesis and cancer. - Abstract - Europe PMC
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Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations | Scientific Reports
Mutations in the POLE exonuclease domain in ECs. (A) Mutations in the... | Download Scientific Diagram
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer | European Journal of Human Genetics
POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status - ScienceDirect
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer | PLOS Genetics
Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer | Journal for ImmunoTherapy of Cancer
Nivolumab Shows Promising Activity in Advanced Tumours with Rare
Cancers | Free Full-Text | The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions | HTML
Church Group — Wellcome Centre for Human Genetics
Exome sequencing reveals a de novo POLD1 mutation causing phenotypic variability in mandibular hypoplasia, deafness, progeroid f